Which of the following prophylactic therapies is recommended to ...

[Sufayan.ah]

Which of the following prophylactic therapies is recommended to reduce the irritant effect of acetylcysteine?
 
  a. Administration of anticholinergics
  b. Administration of dornase alfa
  c. Administration of corticosteroids
  d. Administration of adrenergic bronchodi-lator

Question 2

Which of the following explains how acetylcysteine (Mucomyst) lowers the viscosity of mucus?
 
  a. Breaking down DNA
  b. Increasing the osmolarity of the mucus and pulling water into it
  c. Changing the pH of the mucus, causing it to break down
  d. Substituting its sulfhydryl group for disul-fide bonds and breaking a portion of the bond forming the gel structure

[jrpg123456]

Answer to Question 1

ANS: D
Pretreatment with an adrenergic bronchodilator, allowing adequate time for a bronchodilatory effect to be produced, can prevent or reduce airway resistance with acetylcysteine.

Answer to Question 2

ANS: D
Acetylcysteine acts as a classic mucolytic to reduce the viscosity of mucus by substituting its own sulfhydryl group for the disulfide group in mucus, thereby breaking a portion of the bond forming the gel structure.