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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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Individuals are never “cured” of addictions. Instead, they learn how to manage their disease to lead healthy, balanced lives.
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Nitroglycerin is used to alleviate various heart-related conditions, and it is also the chief component of dynamite (but mixed in a solid clay base to stabilize it).