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As the western states of America were settled, pioneers often had to drink rancid water from ponds and other sources. This often resulted in chronic diarrhea, causing many cases of dehydration and death that could have been avoided if clean water had been available.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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The average adult has about 21 square feet of skin.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Interferon was scarce and expensive until 1980, when the interferon gene was inserted into bacteria using recombinant DNA technology, allowing for mass cultivation and purification from bacterial cultures.