Author Question: Which statement is accurate regarding the use of nicotinic acid (Niacin) for lowering blood ... (Read 43 times)

ericka1 · **on:** Jul 23, 2018

Which statement is accurate regarding the use of nicotinic acid (Niacin) for lowering blood cholesterol levels?

1. It works primarily by lowering LDL and HDL levels.
2. Due to adverse effects, niacin should not be used with statins.
3. Hot flashes are a common side effect when niacin is used in high doses.
4. High doses of 2530 mg per day are often necessary.

Question 2

Atorvastatin (Lipitor) is a statin that can be used to lower blood cholesterol levels by

1. binding exogenous cholesterol and excreting it in the feces.
2. increasing excretion by activating enzymes within the hepatic system.
3. preventing dietary absorption within the GI tract.
4. inhibiting an enzyme that is essential for cholesterol synthesis.

ms_sulzle · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 3
Rationale: Niacin is used as a vitamin supplement in doses of 25 mg/day. The usual dose of 23 grams/day for lowering blood cholesterol levels often results in hot flashes. Niacin lowers LDL levels and increases HDL levels. It is often used with other drugs like the statins.

Answer to Question 2

Correct Answer: 4
Rationale: Statins work by inhibiting the enzyme HMG-CoA reductase. HMG-CoA reductase is essential for cholesterol biosynthesis. Bile acid resins bind cholesterol and promote its excretion in the feces.