Which statement is accurate regarding medications that end up ...

[appyboo]

Which statement is accurate regarding medications that end up being secreted in bile?
 
  1. All medications secreted in bile are excreted in the feces.
  2. Some medications are excreted in the feces while others can be recirculated to the liver many times.
  3. Most medications secreted in bile are metabolized in the gallbladder.
  4. Generally, medications are not secreted in the bile.

Question 2

Which statement regarding medication distribution within the body is accurate?
 
  1. The bloodbrain barrier inhibits rapid crossing of all medications.
  2. Body organs with high levels of blood flow are more difficult organs to which to deliver drugs.
  3. Medications that are lipid-soluble are more completely distributed.
  4. Drugprotein complexes must form prior to crossing capillary membranes.

[sultansheikh]

Answer to Question 1

Correct Answer: 2
Rationale: Most bile is circulated back to the liver by enterohepatic circulation, where medications are metabolized in the liver. Some bile (and medications within) is excreted in the feces.

Answer to Question 2

Correct Answer: 3
Rationale: Lipid-soluble medications are absorbed and distributed quicker and more quickly than those that are not. Body organs with low levels of blood flow are more difficult organs to which to deliver drugs. When medications bind to proteins, their size increases, preventing them from passing through capillary membranes. Some medications (sedatives) are able to rapidly cross the bloodbrain barrier. (pp. 3940)

[appyboo]

Thank you!

[sultansheikh]

Always glad to help...