A patient with a history of seizure disorders is receiving both ...

[B]

A patient with a history of seizure disorders is receiving both ethosuximide (Zarontin) and phen-ytoin (Dilantin). Assess the following serum laboratory test results, and select the one that would indicate an expected drug interaction.
 
  a. Increased ethosuximide concentration
  b. Decreased ethosuximide concentration
  c. Increased phenytoin concentration
  d. Decreased phenytoin concentration

Question 2

The patient is a 15-year-old who has a history of a poorly controlled seizure disorder. His primary care provider tells his parents that he is not a candidate for treatment with phenytoin.
 
  The decision is made based on the need to reduce the patient's risk of developing:
  a. Gingival hyperplasia
  b. Altered mental status
  c. Cardiac arrhythmias
  d. Craniofacial abnormalities

[Zebsrer]

Answer to Question 1

ANS: C
Succinimides, such as ethosuximide, interact with hydantoins, such as phenytoin, to increase se-rum hydantoin levels.

Answer to Question 2

ANS: A
Patients under 23 years of age and those taking phenytoin in dosages exceeding 500 mg/day are at increased risk for gingival hyperplasia.

[B]

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[Zebsrer]

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