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In 1864, the first barbiturate (barbituric acid) was synthesized.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
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Your heart beats over 36 million times a year.