A client is receiving glyburide. The nurse assesses the client ...

[Wadzanai]

A client is receiving glyburide. The nurse assesses the client for a decrease in the drug's effect if which of the following drugs are initiated? Select all that apply.
 
  A) Atenolol (Tenormin)
  B) Amlodipine (Norvasc)
  C) Phenytoin (Dilantin)
  D) Lithium (Eskalith)
  E) Levothyroxine (Synthroid)

Question 2

A client is receiving glipizide at a health care facility. The client is also prescribed an anticoagulant. The nurse would be alert for which of the following related to the interaction of these two drugs?
 
  A) Increased risk of lactic acidosis
  B) Risk of acute renal failure
  C) Increased risk for bleeding
  D) Increased hypoglycemic effect

[bdobbins]

Answer to Question 1

Ans: A, B, C, E
Feedback:
Beta blockers (atenolol), calcium channel blockers (amlodipine), hydantoins (phenytoin), and thyroid agents (levothyroxine), among others, can result in decreased hypoglycemic effects of sulfonylureas (glyburide).

Answer to Question 2

Ans: D
Feedback:
The nurse should observe for increased hypoglycemic effect in the client as the effect of the interaction of sulfonylureas with the anticoagulants, chloramphenicol, clofibrate, fluconazole, histamine-2 antagonists, methyldopa, monoamine oxidase inhibitors (MAOIs), salicylates, sulfonamides, and tricyclic antidepressants. Increased risk of lactic acidosis is an effect of the interaction of metformin with glucocorticoids. Increased risk for bleeding is an effect of the interaction of oral anticoagulants with anti-infective drugs. There is a risk of acute renal failure when iodinated contrast material used for radiologic studies is administered with metformin.

[Wadzanai]

Thanks for the timely response, appreciate it

[ktidd]

Gracias!