Answer to Question 1
1,4
Rationale 1: Intranasal use of this drug can cause burning of the mucosa.
Rationale 2: There is no indication that orange-tinted nasal secretions should be expected.
Rationale 3: Intranasal medications, if used properly, should have little or no effect on blood pressure.
Rationale 4: Rebound congestion is likely to occur if the drug is used for over 35 days.
Rationale 5: There are no known drugherbal interactions with this drug.
Global Rationale: Intranasal use of this drug can cause burning of the mucosa. Rebound congestion is likely to occur if the drug is used for over 35 days. There is no indication that orange-tinted nasal secretions should be expected. Intranasal medications, if used properly, should have little or no effect on blood pressure. There are no known drugherbal interactions with this drug.
Answer to Question 2
1,2,3
Rationale 1: Polystyrene sulfonate (Kayexalate) has an onset of action of 1 hour.
Rationale 2: Sorbitol or another laxative is administered concurrently to promote rapid evacuation of potassium.
Rationale 3: The dose may be repeated in 4 hours if indicated.
Rationale 4: There is no need to mix the dose with a high sugar liquid.
Rationale 5: This drug may be given rectally, but there is no indication to use both routes of delivery.
Global Rationale: Polystyrene sulfonate (Kayexalate) has an onset of action of 1 hour. Sorbitol or another laxative is administered concurrently to promote rapid evacuation of potassium. The dose may be repeated in 4 hours if indicated. There is no need to mix the dose with a high sugar liquid. This drug may be given rectally, but there is no indication to use both routes of delivery.