A drug has been prescribed to decrease the effects of an ...

[kaid0807]

A drug has been prescribed to decrease the effects of an endogenous chemical. The nurse would place this drug in which category?
 
  1. An agonist
  2. A partial agonist
  3. An antagonist
  4. An agonist-antagonist

Question 2

At a dose of 10 mg, drug X lowers total cholesterol by 50 mg/dL, while a maximum drop in cholesterol of 65 mg/dL is achieved at 40 mg. At a dose of 5 mg, drug Y lowers cholesterol by 50 mg/dL, while a maximum drop in cholesterol of 55 mg/dL is achieved at 10 mg. What can be concluded about the efficacy and potency of these two drugs?
 
  1. Drug X is more potent, and drug Y has a higher efficacy.
  2. Drug X is more potent and has higher efficacy.
  3. Drug Y is more potent and has higher efficacy.
  4. Drug Y is more potent, and drug X has a higher efficacy.

[Chocorrol77]

Answer to Question 1

3
Rationale 1: An agonist drug produces the same type of response as the endogenous substance.
Rationale 2: A partial agonist produces a weaker, or less efficacious, response than an agonist.
Rationale 3: An antagonist occupies receptor sites, preventing them from being activated by the medication. This prevents the endogenous chemical from acting.
Rationale 4: An agonist-antagonist produces a weaker, or less efficacious, response than an agonist.
Global Rationale: An antagonist occupies receptor sites, preventing them from being activated by the medication. This prevents the endogenous chemical from acting. An agonist drug produces the same type of response as the endogenous substance. A partial agonist produces a weaker, or less efficacious, response than an agonist. An agonist-antagonist produces a weaker, or less efficacious, response than an agonist.

Answer to Question 2

4
Rationale 1: Drug X is not more potent. Drug Y does not have higher efficacy.
Rationale 2: Drug X is not more potent.
Rationale 3: Drug Y does not have higher efficacy.
Rationale 4: Drug Y causes a greater drop in cholesterol at lower doses (higher potency), whereas drug X causes the highest drop in total cholesterol (efficacy).
Global Rationale: Drug Y causes a greater drop in cholesterol at lower doses (higher potency), whereas drug X causes the highest drop in total cholesterol (efficacy).

[kaid0807]

Excellent

[tanna.moeller]

Gracias!