Author Question: A hospitalized patient is being treated for tuberculosis with a drug regimen that includes ... (Read 42 times)

appyboo · **on:** Jul 23, 2018

A hospitalized patient is being treated for tuberculosis with a drug regimen that includes pyrazinamide. The patient complains of pain in the knee and shoulder joints. The nurse will contact the provider to request an order for:

a. ibuprofen.
b. renal function tests.
c. discontinuation of the pyrazinamide.
d. measurement of uric acid levels.

Question 2

A patient with high-risk factors for tuberculosis will begin therapy for latent TB with isoniazid and rifampin. The nurse learns that this patient takes oral contraceptives. The nurse will counsel this patient to discuss _____ with her provider.

a. another birth control method
b. reducing the rifampin dose
c. reducing the isoniazid dose
d. increasing the oral contraceptive dose

Kaytorgator · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

ANS: A
Polyarthralgias occur in 40 of patients during the initial phase of treatment with pyrazinamide and can be managed with a nonsteroidal anti-inflammatory drug (NSAID). Renal function tests and uric acid levels are not indicated. Unless the pain cannot be managed with NSAIDs, there is no need to reduce the dose of pyrazinamide.

Answer to Question 2

ANS: A
Rifampin induces cytochrome P450 enzymes and can accelerate the metabolism of many drugs, including oral contraceptive pills (OCPs). Women taking OCPs should consider a nonhormonal form of birth control. Reducing the dose of rifampin or isoniazid is not indicated. Increasing the OCP dose is not recommended.