Answer to Question 1
ANS: D
Amoxicillin and ampicillin are similar in structure and actions but differ primarily in acid stability. Amoxicillin is more acid stable and, when administered orally, results in higher blood levels than can be obtained with equivalent doses of ampicillin. The two drugs have the same spectrum, both are inactivated by beta-lactamases, and both can cause allergic reactions.
Answer to Question 2
ANS: C
Penicillinase-resistant penicillins have been developed for use against penicillinase-producing strains of staphylococci. These drugs have a very narrow antimicrobial spectrum and should be used only for such infections. S. pyogenes can be treated with penicillin G. The nurse should question the order. It is incorrect to contact the provider to ask for IV dosing. This infection can be treated with penicillin G and not with vancomycin.
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