A nursing student asks about drugs that interfere with the ...

[notis]

A nursing student asks about drugs that interfere with the termination of transmitter action. Which statement by the nurse is correct?
 
  a. Drugs act on this process by altering the diffusion of the transmitter away from the synaptic gap.
  b. Drugs can interfere with termination by either increasing or decreasing reuptake of the transmitter.
  c. Drugs in this category lead to decreased activation by the transmitter in the synapse.
  d. These drugs reduce either reuptake or degradation of the transmitter, causing an increase in receptor activation.

Question 2

A nurse is teaching a group of nursing students about neuropharmacology. Which statement by a student about peripheral nervous system (PNS) drugs indicates a need for further teaching?
 
  a. Drugs affecting axonal conduction have a variety of uses.
  b. Drugs that alter synaptic transmission can be highly selective.
  c. Many PNS drugs act by altering synaptic transmission.
  d. These drugs work by influencing receptor activity.

[jrpg123456]

Answer to Question 1

ANS: D
Drugs that interfere with termination of transmitter action do so by blocking transmitter reuptake or inhibiting transmitter degradation, resulting in increased receptor activation, because more of the transmitter remains available. Diffusion of the transmitter occurs naturally, but it is a slow process with little clinical significance. Drugs that alter this process cause a decrease in reuptake, not an increase. The effect of drugs that interfere with termination of transmitter action is increased activation.

Answer to Question 2

ANS: A
Local anesthetics are the only drugs shown to work by altering axonal conduction. Any drug affecting axonal conduction would be nonselective, because axonal conduction of impulses is essentially the same in all neurons. In contrast, drugs that affect synaptic transmission can be highly selective, because each transmitter has different effects on receptor sites. Most PNS drugs work on synaptic transmission processes. Through their effects on transmitters, they influence receptor activity.

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[jrpg123456]

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