Agents with antineoplastic activity that have been isolated from ...

[madam-professor]

Agents with antineoplastic activity that have been isolated from a number of plants work in what way?
 
  1. They aid in attachment to the receptor sites on the cancer cell.
  2. They arrest cell division, or mitosis.
  3. They contain substances that have the ability to kill the cancer cells.
  4. They prevent conversion from DNA to RNA.

Question 2

A client shows a proper understanding of the adverse effects of vincristine when he states:
 
  1. I need to let my doctor know immediately if I have any weakness in my hands or feet.
  2. If I have swelling in my legs, I should keep them elevated for a while.
  3. I can take ibuprofen if I have any pain.
  4. I need to let my doctor know immediately if I took two pills instead of one.

[heyhey123]

Answer to Question 1

Correct Answer: 2
Rationale 1: They do not work on the receptor sites.
Rationale 2: They stop cell division, or mitosis.
Rationale 3: They don't contain substances that have the ability to kill the cancer cells.
Rationale 4: They don't prevent conversion from DNA to RNA.
Global Rationale: These substances arrest cell division. They do not work on receptor sites, do not kill cancer cells, and do not prevent conversion from DNA to RNA.

Answer to Question 2

Correct Answer: 1
Rationale 1: This is the correct response.
Rationale 2: Swelling of the legs can indicate a serious adverse reaction, and the client should notify the health care provider if this occurs.
Rationale 3: Pain can indicate an adverse reaction, and the client should not self-medicate but notify the health care provider. Ibuprofen is contraindicated.
Rationale 4: Vincristine is only administered IV, so a client would not take it orally.
Global Rationale: The major dose-limiting toxicity of vincristine is neurotoxicity. This manifests as motor difficulties, peripheral neuropathy, paresthesias (especially of the hands and feet), weakness, cranial nerve palsies (diplopia, hoarseness, deafness, trigeminal neuralgia, vocal cord paralysis), and decreased reflexes. Swelling of the legs can indicate a serious adverse reaction, and the client should notify the health care provider if this occurs. Bone or joint pain can indicate an adverse reaction, and the client should not self-medicate but notify the health care provider. Vincristine is only administered IV, so a client would not take it orally.

[madam-professor]

Excellent

[frankwu0507]

Gracias!