Author Question: The nurse is caring for an obese client who has received thiopental (Pentothal), a lipid-soluble ... (Read 18 times)

maegan_martin · **on:** Jul 23, 2018

The nurse is caring for an obese client who has received thiopental (Pentothal), a lipid-soluble drug, during surgery. Of which fact about the drug should the nurse be aware?

1. It will need to be given at higher than normal doses.
2. It will be stored in adipose tissue.
3. It may have difficulty being distributed to body tissues.
4. It is often ineffective.

Question 2

The nurse has just administered a client's morning dose of medications following a high-fat breakfast. How will the absorption of the medication be affected?

1. It will be blocked.
2. It will be slowed.
3. It will be accelerated.
4. It will not be affected.

nyrave · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 2
Rationale 1: Higher doses of the drug are not necessary.
Rationale 2: Thiopental is a lipid-soluble drug that has a higher affinity for bone marrow, teeth, the eye, and adipose tissue.
Rationale 3: Lipid-soluble drugs are more completely distributed to body tissues.
Rationale 4: The efficacy of the drug is not affected by the lipid solubility.
Global Rationale: Thiopental is a lipid-soluble drug that has a higher affinity for bone marrow, teeth, the eye, and adipose tissue. Higher doses of the drug are not necessary. Lipid-soluble drugs are more completely distributed to body tissues. The efficacy of the drug is not affected by the lipid solubility.

Answer to Question 2

Correct Answer: 2
Rationale 1: Fatty foods will not block absorption of medications.
Rationale 2: Fatty foods in the stomach almost always slow drug absorption.
Rationale 3: Absorption rate will increase if the stomach is empty.
Rationale 4: Most medications are affected by a full or empty stomach.
Global Rationale: Fatty foods in the stomach almost always slow drug absorption. Fatty foods will not block the absorption of medication. The absorption rate will be increased if the stomach is empty. Most medications are affected by either a full or empty stomach.