Answer to Question 1
ANS: C
High-ceiling diuretics are preferred to counteract diazoxide-induced retention of salt and water.
Potassium-sparing diuretics, such as spironolactone, are not the best management of fluid retention caused by diazoxide.
Osmotic diuretics do not prevent retention of salt and water caused by diazoxide.
Thiazide diuretics should be avoided, because they can potentiate the hyperglycemic and hyperuricemic effects of diazoxide.
Answer to Question 2
ANS: B
According to The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High BP (JNC 7) guidelines, a thiazide diuretic is appropriate for use for uncomplicated primary hypertension to reduce blood volume and arterial resistance, as long as the patient does not have renal failure.
The use of two direct-acting vasodilators would result in excessive hypotension and would be contraindicated.
Two diuretics from different groups typically are not prescribed together unless potassium loss has been noted, because use of two diuretics may result in hypotension.
Use of a beta blocker no longer is indicated for uncomplicated primary hypertension unless the patient has heart disease.