Author Question: The nurse is reviewing medication information with a nursing student prior to administering an oral ... (Read 123 times)

lilldybug07 · **on:** Jul 23, 2018

The nurse is reviewing medication information with a nursing student prior to administering an oral drug and notes that the drug has extensive first-pass effects.

Which statement by the student indicates a need for further teaching about this medication?
a. The first-pass effect means the drug may be absorbed into systemic circulation from the intestinal lumen.
b. The first-pass effect means the drug may be changed to an inactive form and excreted.
c. The first-pass effect means the drug may be changed to a metabolite, which may be more active than the original.
d. The first-pass effect means the drug may be unchanged as it passes through the liver.

Question 2

The nurse is preparing an injectable drug and wants to administer it for rapid absorption. How will the nurse give this medication?

a. IM into the deltoid muscle
b. IM into the gluteal muscle
c. SubQ into abdominal tissue
d. SubQ into the upper arm

TheNamesImani · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

ANS: A
Drugs that undergo first-pass metabolism are absorbed into the portal vein from the intestinal lumen and go through the liver where they are either unchanged or are metabolized to an inactive or a more active form.

Answer to Question 2

ANS: A
Drugs given IM are absorbed faster in muscles that have more blood vessels, such as the deltoid, rather than those with fewer blood vessels, such as the gluteals. Subcutaneous routes are used when absorption needs to be slower and more sustained.