What are the therapeutic and adverse effects associated with the ...

[Pineappleeh]

What are the therapeutic and adverse effects associated with the adrenergic blocking agents related to?
 
  A) Receptor-site specificity
  B) Sympathetic nervous system manifestations
  C) Norepinephrine release
  D) Function of the nerve terminal

Question 2

A patient's medication has been changed to clozapine (Clozaril). The nurse evaluates this patient for which life-threatening adverse effect?
 
  A) Renal insufficiency
  B) Emphysema
  C) Neuroleptic malignant syndrome
  D) Cerebrovascular accident (CVA)

[nyrave]

Answer to Question 1

A
Feedback:
The therapeutic and adverse effects associated with these drugs are related to their adrenergic-receptor-site specificity; that is, the ability to react with specific adrenergic receptor sites without activating them, thus preventing the typical manifestations of sympathetic nervous system (SNS) activation. By occupying the adrenergic receptor site, they prevent norepinephrine released from the nerve terminal or from the adrenal medulla from activating the receptor, thus blocking the SNS effects.

Answer to Question 2

C
Feedback:
Neuroleptic malignant syndrome can be a life-threatening adverse effect of atypical non-phenothiazines. Renal insufficiency, emphysema, and CVA are not commonly seen adverse effects of atypical non-phenothiazines.

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