Cruciferous vegetables may alter drug pharmacokinetics by: 1. ...

[Collmarie]

Cruciferous vegetables may alter drug pharmacokinetics by:
 
  1. Enhancing absorption of weakly acidic drugs
  2. Altering CYP 3A4 activity, leading to elevated levels of drugs, such as the statins
  3. Inducing CYP 1A2, possibly leading to therapeutic failure of drugs metabolized by CYP 1A2
  4. Decreasing first-pass metabolism of drugs

Question 2

Grapefruit juice contains furanocoumarins that have been found to:
 
  1. Alter absorption of drugs through competition for binding sites
  2. Inhibit CYP 3A4, leading to decreased first-pass metabolism of drugs
  3. Alter vitamin K metabolism, leading to prolonged bleeding
  4. Enhance absorption of calcium and vitamin D

[akudia]

Answer to Question 1

3

Answer to Question 2

2

[Collmarie]

TYSM

[ricroger]

Thanks for the timely response, appreciate it