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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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To combat osteoporosis, changes in lifestyle and diet are recommended. At-risk patients should include 1,200 to 1,500 mg of calcium daily either via dietary means or with supplements.
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Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.