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According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.
The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
Addicts to opiates often avoid treatment because they are afraid of withdrawal. Though unpleasant, with proper management, withdrawal is rarely fatal and passes relatively quickly.
Thyroid conditions may make getting pregnant impossible.
Human kidneys will clean about 1 million gallons of blood in an average lifetime.