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Author Question: What part does methylmalonic acid play in the metabolism of B12? Why would the physician analyze for ... (Read 21 times)

torybrooks

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on: Aug 2, 2018
What part does methylmalonic acid play in the metabolism of B12? Why would the physician analyze for this compound?

Question 2

Illustrate the pathway that converts homocysteine to cysteine or to methionine. Show the need for B6, B12, and folic acid.


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jaaaaaaa

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Reply #1 on: Aug 2, 2018
Answer to Question 1

If serum B12 levels are measured, they do not reveal the amount of B12 on a tissue level. Serum B12 could be normal with a low tissue level. Methylmalonic, a metabolite in the B12 pathway is a more accurate indicator of B12 on the tissue level.

Answer to Question 2

This should be done in a schematic format and should include the pathways involving homocysteine conversion and illustrating where the B vitamins are involved. These pathways are available in basic biochemistry texts and most advanced nutrition texts.


torybrooks

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Reply 2 on: Aug 2, 2018
Thanks for the timely response, appreciate it

nyrave

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Reply 3 on: Yesterday
Great answer, keep it coming :)

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