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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
Patients should never assume they are being given the appropriate drugs. They should make sure they know which drugs are being prescribed, and always double-check that the drugs received match the prescription.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.
The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.