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Side effects from substance abuse include nausea, dehydration, reduced productivitiy, and dependence. Though these effects usually worsen over time, the constant need for the substance often overcomes rational thinking.
Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.
The average human gut is home to perhaps 500 to 1,000 different species of bacteria.
When Gabriel Fahrenheit invented the first mercury thermometer, he called "zero degrees" the lowest temperature he was able to attain with a mixture of ice and salt. For the upper point of his scale, he used 96°, which he measured as normal human body temperature (we know it to be 98.6° today because of more accurate thermometers).
In 1864, the first barbiturate (barbituric acid) was synthesized.

