Answer to Question 1
Plaque deposits are made from fats, cholesterol, and other substances, which accumulate over time thickening and weakening artery walls. The plaques develop within rather than on the artery wall and are driven by an inflammatory process. The plaque reduces the size of the lumen, resulting in a decreased amount of blood flow to the tissues. The reduced flow prevents an adequate supply of nutrients and oxygen from reaching the tissues.
Answer to Question 2
Component of all body tissues providing structure and form; participates in many chemical reactions; serves as solvent for minerals, vitamins, amino acids, glucose, and other small molecules or waste products; acts as lubricant and cushion around joints as a shock absorber; assists in regulation of body temperature by evaporation and perspiration; essential for hydrolysis and metabolism; aids in digestion; bathes eyes, spinal cord; makes up the amniotic fluid that surrounds the fetus.