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It is believed that humans initially contracted crabs from gorillas about 3 million years ago from either sleeping in gorilla nests or eating the apes.
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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.
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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.