Why might someone diagnosed with a vitamin B6 deficiency be ...

[awywial]

Why might someone diagnosed with a vitamin B6 deficiency be fatigued? Explain.

Question 2

Therapeutic doses of niacin have been shown to lower cholesterol; however, taking too much niacin is harmful. How much is too much, and what are the harmful effects?

[Liamb2179]

Answer to Question 1

Vitamin B6 deficiency results in inadequate heme production, which lowers concentrations of hemoglobin in red blood cells (RBC). RBC are then unable to deliver sufficient oxygen to the tissues, and this impairs their ability to produce ATP via aerobic metabolism, causing fatigue.

Answer to Question 2

UL for niacin = 35 mg per day from supplements and fortified foods. Harmful effects include increased plasma glucose and damage to the liver.