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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
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In most climates, 8 to 10 glasses of water per day is recommended for adults. The best indicator for adequate fluid intake is frequent, clear urination.
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It is difficult to obtain enough calcium without consuming milk or other dairy foods.