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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
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As of mid-2016, 18.2 million people were receiving advanced retroviral therapy (ART) worldwide. This represents between 43–50% of the 34–39.8 million people living with HIV.
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Essential fatty acids have been shown to be effective against ulcers, asthma, dental cavities, and skin disorders such as acne.