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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Each year in the United States, there are approximately six million pregnancies. This means that at any one time, about 4% of women in the United States are pregnant.
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Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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The longest a person has survived after a heart transplant is 24 years.