Answer to Question 1
Metformin is an antihyperglycemic agent for diabetes and it works by decreasing the production of glucose by the liver. Additionally, will stimulate GLUT4 translocation in skeletal muscle, thereby decreasing insulin resistance.
Answer to Question 2
Metabolic syndrome? - Yes - fasting blood glucose 100 mg/dL (121 mg/dL), triglycerides 150 mg/dL (350 mg/dL), blood pressure 130/85 mmHg (142/86 mmHg)
Meeting 3 of the 5 criteria is diagnostic for metabolic syndrome (the other criteria is an HDL < 40 mg/dL and a waist circumference > 40 in (102 cm) for men)
Nutrition intervention crossover:
- Weight loss (lowers blood pressure and insulin resistance)
- Alcohol cessation (lowers blood pressure)
- Increase in antioxidants (help reduce inflammation associated with insulin resistance and prevent atherosclerotic plaques associated with oxidized LDL)
- Increase in fiber content (reduce hyperlipidema - cholesterol and LDL levels)
- Physical activity for weight loss (increase HDL and insulin sensitivity)
- Overall treatment of NAFLD may reduce the elevated triglyceride production associated with NAFLD
p53 mechanism
Gingival enlargement in a patient taking phenytoin.
Action of bile salts in emulsifying fats in the intestine
Schematic depiction of the action of tryptophan synthase in one functional unit
Structure and action of the T7 phage gene 4 helicase
A mechanism for peptidyltransferase involving A2451 (E. coli) as a general base