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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
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Approximately 500,000 babies are born each year in the United States to teenage mothers.