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Illicit drug use costs the United States approximately $181 billion every year.
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In 1886, William Bates reported on the discovery of a substance produced by the adrenal gland that turned out to be epinephrine (adrenaline). In 1904, this drug was first artificially synthesized by Friedrich Stolz.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Side effects from substance abuse include nausea, dehydration, reduced productivitiy, and dependence. Though these effects usually worsen over time, the constant need for the substance often overcomes rational thinking.
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On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.