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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
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Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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The most destructive flu epidemic of all times in recorded history occurred in 1918, with approximately 20 million deaths worldwide.