Answer to Question 1
This test relies on measuring total creatinine excreted in the urine in 24 hours and measuring the plasma concentration of creatinine. Since essentially none of the filtered load is returned to bloodstream, the amount in the urine relates directly to the volume of blood that filtered in the glomeruli. GFR can be calculated by dividing creatinine excretion rate (mg/hr) by plasma concentration of creatinine (g/dL) to get the GFR in dL/hour, from which the per-minute rate is calculated by dividing by 60. The test is not entirely accurate because up to 15 percent of the excreted creatinine enters the urine by tubular secretion.
Answer to Question 2
D