Answer to Question 1
Levels of ghrelin, a hormone produced by P/D1 cells, lining the fundic region of the stomach, rise before meals to initiate hunger and decline shortly after eating to curb appetite. Ghrelin is also antagonistic to leptin, a fat-tissue-derived hormone that induces satiety. Another hormone from the stomach and small intestine, obestatin, decreases appetite. The same gene encodes both ghrelin and obestatin.
Answer to Question 2
D