The effective dose 50 (ED50) value for Drug A is 2.0 mg/kg while ...

[jeatrice]

The effective dose 50 (ED50) value for Drug A is 2.0 mg/kg while its lethal dose 50 (LD50) value is 8 mg/kg. Which of the following is true of Drug A?
 
  A) Drug A is ineffective for its intended purpose.
  B) Drug A has a therapeutic index of 4.0.
  C) Drug A is safe for use in humans.
  D) The therapeutic index of Drug A is 0.25.
  E) The therapeutic index of Drug A is 25.

Question 2

Repeated administration of a constant drug dose typically produces ________, which is defined as a(n) ________ effect of the drug.
 
  A) dynamic capacity; increased
  B) sensitization; reduced
  C) behavioral inactivation; increased
  D) tolerance; reduced
  E) homeostasis; constant

[yotaSR5]

Answer to Question 1

Answer: B
Rationale: Assuming that Drug A has an ED50 value of 2.0 mg/kg while its lethal dose 50 (LD50) value is 8 mg/kg, Drug A has a therapeutic index of 4.0.

Answer to Question 2

Answer: D
Rationale: Repeated administration of a constant drug dose typically produces tolerance, which is defined as a reduced effect of the drug over time.

[jeatrice]

Thank you

[yotaSR5]

No problem