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Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.

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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.

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Elderly adults are living longer, and causes of death are shifting. At the same time, autopsy rates are at or near their lowest in history.

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Nearly 31 million adults in America have a total cholesterol level that is more than 240 mg per dL.

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In 1864, the first barbiturate (barbituric acid) was synthesized.

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