One mechanism for the tolerance produced by repeated drug administration is a(n)
a. decreased metabolism of the drug.
b. increased plasma level of the drug.
c. increased number of receptors in the brain.
d. reduced number of receptors for the drug.
e. increased number of ion channel openings in response to receptor activation.
Question 2
After two years, Sam needs to smoke more cigarettes to achieve the same feelings as he had when he first started smoking. This need to increase dosage is due to
a. dynamic capacity.
b. sensitization.
c. inactivation.
d. tolerance.
e. binding capacity.
A new drug development timeline, with the four phases of drug approval
Intradermal drug administration: (b) the administration site is prepped Source: Pearson Education/PH
Intramuscular drug administration: (a) cross section of skin showing depth of needle insertion
p53 mechanism
Therapeutic index: (a) Drug X has a therapeutic index of 4. (b) Drug Z has a therapeutic index of 2.
Drug A is more potent than Drugs B and C. Drugs A and C have equal efficacy because both drugs have ...