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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.
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The average adult has about 21 square feet of skin.
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The highest suicide rate in the United States is among people ages 65 years and older. Almost 15% of people in this age group commit suicide every year.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.