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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
The modern decimal position system was the invention of the Hindus (around 800 AD), involving the placing of numerals to indicate their value (units, tens, hundreds, and so on).
When intravenous medications are involved in adverse drug events, their harmful effects may occur more rapidly, and be more severe than errors with oral medications. This is due to the direct administration into the bloodstream.
In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.