Mean platelet volume (MPV) in humans increases with heart attacks and strokes and is used to predict recurrence as well as mortality. MPV has high heritability. A recent GWA study found MPV to be associated with SNPs on chromosomes 12, 3, and 17, respectively. These three QTLs accounted for 4-5% of MPV variance. Which of the following is a reasonable explanation?
◦ Other loci may also account for significant variance of MPV.
◦ These SNPs must be translocated or transposed alleles.
◦ Monitoring of these SNPs should identify those at highest risk.
◦ The three SNPs, when sequenced, should show high conservation.
◦ The three SNPs will be found in genes responsible for stroke.