One of the human leukemias, called CML (chronic myelogenous leukemia), is associated with a chromosomal translocation between chromosomes 9 and 22 in somatic cells of bone marrow. Which of the following allows CML to provide further evidence of this multistep nature of cancer?
A) CML usually occurs in more elderly persons (late age of onset).
B) The resulting chromosome 22 is abnormally short; it is then known as the Philadelphia chromosome.
C) The translocation requires breaks in both chromosomes 9 and 22, followed by fusion between the reciprocal pieces.
D) CML involves a proto-oncogene known as abl.
E) CML can usually be treated by chemotherapy.
The formation of a chimeric gene that is found in people with certain forms of leukemia.
A comparison between chromosomes found in a normal human cell and a cancer cell from the same person
Caucasian Human Skull
24 weeks old human fetus
A simplified diagram of the Human Ear
The traditional human karyotypes derived from a normal female and a normal male