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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Barbituric acid, the base material of barbiturates, was first synthesized in 1863 by Adolph von Bayer. His company later went on to synthesize aspirin for the first time, and Bayer aspirin is still a popular brand today.
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The B-complex vitamins and vitamin C are not stored in the body and must be replaced each day.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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Approximately 500,000 babies are born each year in the United States to teenage mothers.