Author Question: Which of the following alkylating agents can cross the blood-brain barrier? Select all that apply. ... (Read 51 times)

2125004343 · **on:** Jul 23, 2018

Which of the following alkylating agents can cross the blood-brain barrier? Select all that apply.

A) Cisplatin (Platinol-AQ)
B) Melphalan (Alkeran)
C) Carmustine (BiCNU)
D) Streptozocin (Zanosar)
E) Mechlorethamine (Mustargen)

Question 2

After reviewing information about colony-stimulating factors, a group of nursing students demonstrate understanding of the information when they identify which of the following as true about filgrastim (Neupogen)? Select all that apply.

A) Is a glycoprotein
B) Promotes proliferation of leukocytes
C) Stimulates differentiation of erythrocytes
D) Stimulates maturation of megakaryocytes
E) Is used to treat chemotherapy-induced neutropenia

Galvarado142 · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Ans: C, D
Feedback:
Nitrosoureas, like carmustine (BiCNU) and streptozocin (Zanosar), are alkylating agents that can cross the blood-brain barrier.

Answer to Question 2

Ans: A, B, E
Feedback:
Colony-stimulating factors such as filgrastim (Neupogen) are glycoproteins used to stimulate proliferation, differentiation, and maturation of leukocytes. They are used to treat chemotherapy-induced neutropenia.