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In 1864, the first barbiturate (barbituric acid) was synthesized.
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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.
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Cyanide works by making the human body unable to use oxygen.
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Many supplement containers do not even contain what their labels say. There are many documented reports of products containing much less, or more, that what is listed on their labels. They may also contain undisclosed prescription drugs and even contaminants.
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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.