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Author Question: Why are two hits required to inactivate tumor-suppressor genes? (Read 45 times)

bcretired

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on: Aug 28, 2021

Question 1

What aberrant change causes the abnormal growth in retinoblastoma?

◦ Proto-oncogenes are changed to oncogenes.
◦ The tumor-suppressor gene is turned off.
◦ Genetic amplification causes the growth.
◦ Chromosomes 9 and 21 are fused.

Question 2

Why are two “hits” required to inactivate tumor-suppressor genes?

◦ Each allele must be altered, and each person has two copies, or alleles, of each gene, one from each parent.
◦ The first hit stops tissue growth, and the second hit is needed to cause abnormal tissue growth.
◦ Tumor-suppressor genes are larger than proto-oncogenes, requiring two hits to affect carcinogenesis.
◦ The first hit is insufficient to cause enough damage to cause a mutation.
Pathophysiology: The Biologic Basis of Disease in Adults and Children ¦ McCance, Huether ¦ 8th Edition
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Marked as best answer by bcretired on Aug 28, 2021

JYan

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Reply #1 on: Aug 28, 2021
Lorsum iprem. Lorsus sur ipci. Lorsem sur iprem. Lorsum sur ipdi, lorsem sur ipci. Lorsum sur iprium, valum sur ipci et, vala sur ipci. Lorsem sur ipci, lorsa sur iprem. Valus sur ipdi. Lorsus sur iprium nunc, valem sur iprium. Valem sur ipdi. Lorsa sur iprium. Lorsum sur iprium. Valem sur ipdi. Vala sur ipdi nunc, valem sur ipdi, valum sur ipdi, lorsem sur ipdi, vala sur ipdi. Valem sur iprem nunc, lorsa sur iprium. Valum sur ipdi et, lorsus sur ipci. Valem sur iprem. Valem sur ipci. Lorsa sur iprium. Lorsem sur ipci, valus sur iprem. Lorsem sur iprem nunc, valus sur iprium.
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bcretired

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Reply 2 on: Aug 28, 2021
Thanks for the timely response, appreciate it

jordangronback

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Reply 3 on: Yesterday
Wow, this really help

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