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Author Question: Why are two hits required to inactivate tumor-suppressor genes? (Read 28 times)

bcretired

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on: Aug 28, 2021

Question 1

What aberrant change causes the abnormal growth in retinoblastoma?

◦ Proto-oncogenes are changed to oncogenes.
◦ The tumor-suppressor gene is turned off.
◦ Genetic amplification causes the growth.
◦ Chromosomes 9 and 21 are fused.

Question 2

Why are two “hits” required to inactivate tumor-suppressor genes?

◦ Each allele must be altered, and each person has two copies, or alleles, of each gene, one from each parent.
◦ The first hit stops tissue growth, and the second hit is needed to cause abnormal tissue growth.
◦ Tumor-suppressor genes are larger than proto-oncogenes, requiring two hits to affect carcinogenesis.
◦ The first hit is insufficient to cause enough damage to cause a mutation.
Pathophysiology: The Biologic Basis of Disease in Adults and Children ¦ McCance, Huether ¦ 8th Edition
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Marked as best answer by bcretired on Aug 28, 2021

JYan

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Reply #1 on: Aug 28, 2021
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bcretired

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Reply 2 on: Aug 28, 2021
Wow, this really help

T4T

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Reply 3 on: Yesterday
Gracias!

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