This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Why are two hits required to inactivate tumor-suppressor genes? (Read 72 times)

bcretired

  • Hero Member
  • *****
  • Posts: 525
on: Aug 28, 2021

Question 1

What aberrant change causes the abnormal growth in retinoblastoma?

◦ Proto-oncogenes are changed to oncogenes.
◦ The tumor-suppressor gene is turned off.
◦ Genetic amplification causes the growth.
◦ Chromosomes 9 and 21 are fused.

Question 2

Why are two “hits” required to inactivate tumor-suppressor genes?

◦ Each allele must be altered, and each person has two copies, or alleles, of each gene, one from each parent.
◦ The first hit stops tissue growth, and the second hit is needed to cause abnormal tissue growth.
◦ Tumor-suppressor genes are larger than proto-oncogenes, requiring two hits to affect carcinogenesis.
◦ The first hit is insufficient to cause enough damage to cause a mutation.
Pathophysiology: The Biologic Basis of Disease in Adults and Children ¦ McCance, Huether ¦ 8th Edition
Buy Test-Bank


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by bcretired on Aug 28, 2021

JYan

  • Sr. Member
  • ****
  • Posts: 331
Reply #1 on: Aug 28, 2021
Lorsum iprem. Lorsus sur ipci. Lorsem sur iprem. Lorsum sur ipdi, lorsem sur ipci. Lorsum sur iprium, valum sur ipci et, vala sur ipci. Lorsem sur ipci, lorsa sur iprem. Valus sur ipdi. Lorsus sur iprium nunc, valem sur iprium. Valem sur ipdi. Lorsa sur iprium. Lorsum sur iprium. Valem sur ipdi. Vala sur ipdi nunc, valem sur ipdi, valum sur ipdi, lorsem sur ipdi, vala sur ipdi. Valem sur iprem nunc, lorsa sur iprium. Valum sur ipdi et, lorsus sur ipci. Valem sur iprem. Valem sur ipci. Lorsa sur iprium. Lorsem sur ipci, valus sur iprem. Lorsem sur iprem nunc, valus sur iprium.
Answer Preview
Only 39% of students answer this correctly


bcretired

  • Member
  • Posts: 525
Reply 2 on: Aug 28, 2021
Excellent

patma1981

  • Member
  • Posts: 292
Reply 3 on: Yesterday
Thanks for the timely response, appreciate it

« previous next »
 

Did you know?

Carbamazepine can interfere with the results of home pregnancy tests. If you are taking carbamazepine, do not try to test for pregnancy at home.

Did you know?

Your skin wrinkles if you stay in the bathtub a long time because the outermost layer of skin (which consists of dead keratin) swells when it absorbs water. It is tightly attached to the skin below it, so it compensates for the increased area by wrinkling. This happens to the hands and feet because they have the thickest layer of dead keratin cells.

Did you know?

Signs of depression include feeling sad most of the time for 2 weeks or longer; loss of interest in things normally enjoyed; lack of energy; sleep and appetite disturbances; weight changes; feelings of hopelessness, helplessness, or worthlessness; an inability to make decisions; and thoughts of death and suicide.

Did you know?

Malaria was not eliminated in the United States until 1951. The term eliminated means that no new cases arise in a country for 3 years.

Did you know?

Pregnant women usually experience a heightened sense of smell beginning late in the first trimester. Some experts call this the body's way of protecting a pregnant woman from foods that are unsafe for the fetus.

Relatively simple changes in Hox genes control limb formation in tetrapods. Relatively simple changes in Hox genes control limb formation in tetrapods.
Identical twins share 100 percent of their segregating genes. Identical twins share 100 percent of their segregating genes.
Mammograms. (A) Mammogram procedure. (B) Film of normal breast. (C) Film of breast with tumor. Mammograms. (A) Mammogram procedure. (B) Film of normal breast. (C) Film of breast with tumor.
Metastatic spread of the tumor shown with imaging techniques. Metastatic spread of the tumor shown with imaging techniques.
Polygenic inheritance of wheat kernel color controlled by two additive genes Polygenic inheritance of wheat kernel color controlled by two additive genes
Morgan’s test-cross analysis of genetic linkage between autosomal genes Morgan’s test-cross analysis of genetic linkage between autosomal genes
Video: ADH and the arterioles, kidneys, sweat glands and the Atrial natriuretic peptide (ANP)

For a complete list of videos, visit our video library