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Author Question: DNA helicase inhibitors are well studied as potential drug targets. What would you expect to seeif ... (Read 19 times)

CORALGRILL2014

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DNA helicase inhibitors are well studied as potential drug targets. What would you expect to see 
if DNA helicase activity is inhibited?
◦ The replisome complex would not assemble on the oriC region.
◦ The DNA cannot bend, so hydrogen bonds in the 13-mer region of oriC remain intact.
◦ Helicase catalyzes ATP hydrolysis and DNA strands separation, so the helix cannot be unwound and strands will not separate.
◦ Helicase carries the SSB protein to the open region of DNA, so hydrolysis and strand separation will not occur.
◦ Helicase prevents reannealing of the separated strands, so strands would quickly reanneal and DNA replication cannot proceed.


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Marked as best answer by CORALGRILL2014 on Jan 12, 2022

ansleighelindsey

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CORALGRILL2014

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Reply 2 on: Jan 12, 2022
Thanks for the timely response, appreciate it


daiying98

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Reply 3 on: Yesterday
:D TYSM

 

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